It is a colourless salt, but commercial samples can appear tan. Acute toxicity oral category 2 acute toxicity dermal category 2 acute toxicity inhalation category 2. Sodium tetrahydroborate powder recommended use laboratory chemicals. Since the reaction rate for the reduction of iminium ions is much faster than for ketones or even aldehydes, the reductive amination can be carried out as a onepot procedure by introducing the reducing agent into a mixture of the amine and carbonyl compound. Uses advised against not for food, drug, pesticide or biocidal product use details of the supplier of the safety data sheet emergency telephone number. The cyanoborohydride offers five times milder reduction compared to borohydride in the reductive amination process, reducing the schiffs bases. Extinguishing media suitable extinguishing media use dry powder, dry sand or dry earth to extinguish. This white solid, usually encountered as a powder, is a reducing agent that finds application in chemistry, both in the laboratory and on an industrial scale. Sodium cyanoborohydride is preferred as a reducing agent over sodium borohydride as the latter will also reduce the reactive aldehydes to hydroxyls at the same time as reducing the schiffs bases. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Alexander shulgin in pihkal discusses the use of sodium cyanoborohydride reductive amination but only for very small batches.
Special hazards arising from the substance or mixture specific hazards contact with acids liberates very toxic gas. Working with hazardous chemicals organic syntheses. Seastar chemicals inc msds hydrofluoric acid page 1 of 7 material safety data sheet hydrofluoric acid print date. It is a versatile reducing agent for the reductive amination of carbonyl compounds and reduction of imines. The following information includes the chemical characteristics of followed by recommendations for handling and any paperwork needed in order to use the chemical in the laboratory. Sodium borohydride 16940662 sodium tetrahydroborate sodium borohydride nabh4 contact information. Sigmaaldrich offers a number of sodium cyanoborohydride products. Accordingly, the ph value should be adjusted to between 5 and 11.
Sodium borohydride, also known as sodium tetrahydridoborate and sodium tetrahydroborate, is an inorganic compound with the formula na bh 4. Reductive methylation of protein amino groups with formaldehyde and sodium cyanoborohydride is shown to give up to 25% yield of ncyanomethyl ch2cn product. Procedures for the disposal of liquid chemical residues. How can i handle and dispose sodium cyanoborohydride. Selective reducing agent for aldehydes, ketones, oximes, enamines. Allowing the material to come into contact with water or moist air may decompose the material and could lead to a violent reaction or explosion due to the release of hydrogen gas. Acute toxicity oral category 2 acute toxicity dermal category 2.
Sodium cyanoborohydride solution american elements. Sodium triacetoxyborohydride nabhoac 3 is particularly effective in reductive aminations due to its large scope, mildness, and selectivity. Sodium cyanoborohydride nabh3cn is a mild reducing agent that is commonly used in reductive aminations. Ltri chemical inventory sheet and msds linksjanuary 2016. Highly acidic or alkaline solutions may damage the pipes. Msds contains all of the information required by those regulations. American elements produces to many standard grades when applicable, including mil spec military grade. Sodium cyanoborohydride solution is generally immediately available in most volumes. Sodium borohydride msds material safety data sheet or sds, coa and coq, dossiers, brochures and other available documents. Optical grade, usp and epbp european pharmacopoeia. Eye contact rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Canadian ingredient disclosure list section 16 additional information msds creation date. It is widely used in organic synthesis for the reduction of imines.
Properties of aqueous alkaline sodium borohydride solutions. Optical grade, usp and epbp european pharmacopoeiabritish. Sodium cyanoborohydride is toxic, prepare in a fume hood. Our msds database is an easy to use, do it yourself tool, and best of all. Biotage mpcyanoborohydride is a macroporous polymer supported cyanoborohydride. Safety data sheet according to federal register vol. I am considering using sodium cyanoborohydride in a reductive nalkylation of a polysaccharide, and want to know how to handle it safely and dispose of the nitrile byproduct. In case of more serious fires, also alcoholresistant foam and water spray. The reaction workup protocol is greatly simplified by using the solid supported reagent. Sodium cyanoborohydride reagent grade american elements. Firstaid measures general advice immediate medical attention is required. Procedures for the disposal of liquid chemical residues and aqueous solutions. Thermo scientific aminolink reductant sodium cyanoborohydride promotes the formation of stable bonds between aldehyde and aminecontaining molecules, enabling efficient labeling, conjugation, and immobilization of proteins and other molecules.
Material safety data sheet hydrofluoric acid print date. High purity, submicron and nanopowder forms may be considered. September 2011 section 1 chemical product and company identification msds name. Ac168550000, ac168550100, ac168550500, ac168552500, ac95569, ac9584945, ac9584951 ac9584951 synonyms. Sodium cyanoborohydride revision date 19january2018 eye contact in the case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Laboratory chemicals gloucester house farnborough road farnborough united kingdom telephone uk. View product specific information, msds, references and buying faq. Dissolve the amine or hydrazide containing molecule protein in pbs at a concentration of 10mgml. It can be prepared either by treating sodium cyanide with borane, or by reacting sodium borohydride with mercuryii cyanide. Skin contact wash off immediately with plenty of water for at least 15 minutes.
Use fireextinguishing media suitable for the surrounding fire. Sodium cyanoborohydride is the chemical compound with the formula na b h 3 cn. The presence of the electronwithdrawing cyano cn group makes it less reactive than sodium borohydride. Identification product name sodium borohydride cat no. And it is usually used as a mild reducing agent which converts imines to amines. Sodium cyanoborohydride msds material safety data sheet or sds, coa and coq, dossiers, brochures and other available documents. Sodium cyanoborohydride mda reaction conditions, hive. Department of chemistry, university of minnesota, minneapolis, minnesota 55455.
Sodium cyanoborohydride, sodium cyanotrihydroborate. Properties of aqueous alkaline sodium borohydride solutions and byproducts formed during hydrolysis presented at the fuel cell design, fabrication and materials selection workshop grainger engineering library, room 335 1 w. Owing to the presence of the electronwithdrawing cyanide. Buy sodium cyanoborohydride cas 25895607, a highly selective reducing agent for reductive amination, from santa cruz.
When dissolved in water, hydrogen gas is formed as a reaction byproduct. Download msds pdf search msds currently available for download bioworld offers sodium cyanoborohydride for your research at low price. Eye contact in the case of contact with eyes, rinse immediately with plenty of water and seek medical advice. When using scbh in reductive amination, the ph must be maintained in the range of 68. This reduced reactivity allows nabh3cn to be employed at neutral or slightly acidic conditions for the selective reduction of iminium. Sodium cyanoborohydride reagent grade, 95% sigmaaldrich. View detailed export data, price, monthly trends, major exporting countries, major ports of sodium cyanoborohydride. Sodium triacetoxyborohydride, also known as sodium triacetoxyhydroborate, commonly. University illinois urbana champaign urbana, illinois 61801 july 2627, 2005 by. Uses advised against not for food, drug, pesticide or biocidal product use details of the supplier of the safety data sheet emergency telephone number chemtreco, inside the usa. Safety data sheet 112030 sodium triacetoxyborohydride. Sodium borohydride cas 16940662 106371 merck millipore.
Sodium cyanoborohydride reductive amination of phenylacetone or 3,4mdp2p can give up to 98% yield in very large batches with no side reactions. Weve included the most sought after safety data sheets, and the database just keeps growing. Sodium cyanoborohydride reducing agent product code. Sds of sodium cyanoborohydride, safety data sheets, cas 25895. Use of the information, documents and data from the echa website is subject to the terms and conditions of this legal notice, and subject to other binding. Sds of sodium cyanoborohydride, safety data sheets, cas. Cyanoborohydride according to the material safety data sheet msds special precautions must be taken when working with the chemical described above. Chemicalbook provide chemical industry users with sodium cyanoborohydride boiling point melting point,sodium cyanoborohydride density msds formula use,if you also need to sodium cyanoborohydride. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Reductive alkylation of amines, hydrazines sodium cyanoborohydride is used as a reagent involved in the reductive amination of aldehydes, ketones, oximes and enamines. Sodium cyanoborohydride cas 25895607 scbt santa cruz. Why sodium cyanoborohydride reactivity depends on ph.
Sodium cyanoborohydride is a very hygroscopic material and contact with water or moist air should be avoided. Sodium borohydride is soluble in water, but it reacts with water in absence of base. Reductive amination of mdp2p using sodium cyanoborohydride. Sodium cyanoborohydride is especially suitable for reductive aminations. It is also used in the reductive alkylation of amines and hydrazines. Articles of sodium cyanoborohydride are included as well. One reagent lane fair lawn, nj 07410 for information in north america, call. Thermo scientific aminolink reductant sodium cyanoborohydride promotes the. Export data and price of sodium cyanoborohydride zauba. Carbonyl groups such as aldehydes, ketones, and glyox.
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